Toxoplasma gondii is capable of actively invading almost any mammalian cell type including phagocytes.Early events in phagocytic cells such as dendritic cells are not only key to establishing parasite infection, but conversely play a pivotal role in initiating host immunity.It is now recognized that in addition to changes in canonical immune marker
BackgroundMutations in a novel gene, UBIAD1, were recently found to cause the autosomal dominant eye disease Schnyder corneal dystrophy (SCD).SCD is characterized by an abnormal deposition of cholesterol and phospholipids in the cornea resulting in progressive corneal opacification and visual loss.We characterized lesions in the UBIAD1 gene in new
A key component of increasing energy access globally is providing rural electrification using off-grid minigrids.Minigrid developers have specific design and planning needs including: (i) equipment sizing and resource allocation, (ii) distribution network layout, and (iii) reliability cost-benefit analysis.Optimization of each aspect is necessary t
In the title compound, C24H19ClN2O3S, the sulfonyl-bound benzene ring forms dihedral angles of 38.1 (2) and 81.2 (1)°, respectively, with the formyl benzene and benzene rings.The molecular conformation is stabilized by a Foot Cream weak intramolecular C—H.O hydrogen bond, which generates an S(5) ring motif.The